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An international perspective on the prevalence of the Wernicke-Korsakoff syndrome

Identifieur interne : 00D526 ( Main/Exploration ); précédent : 00D525; suivant : 00D527

An international perspective on the prevalence of the Wernicke-Korsakoff syndrome

Auteurs : Clive Harper [Australie] ; Paul Fornes [France] ; Charles Duyckaerts [France] ; Dominique Lecomte [France] ; Jean-Jacques Hauw [France]

Source :

Metabolic Brain Disease [ 0885-7490 ] ; 1995-03-01.

RBID : ISTEX:9F7BA68D52E2AABBA6C41F8875F008BEE46A1340

English descriptors

Abstract

Abstract: In the Western world previous studies have shown that the majority of cases of the Wernicke-Korsakoff syndrome (WKS), which is caused by thiamine deficiency, occur in alcoholics. However, in France, a country with one of the highest per capita consumptions of alcohol, the prevalence of the WKS was found to be only 0.4% in a small retrospective autopsy study. This figure is compared with data sent to the authors by a number of neuropathologists from the U.S.A., Europe, Scandinavia and Australia. There was no obvious correlation between the prevalence rates of the WKS, which were highest in Australia (2.8% - previously published), and per capita consumption of alcohol. Other issues such as diet, National programs for supplementation of foods with thiamine, and drinking habits are considered. The pathological diagnosis of the WKS can often be made on macroscopic examination of the brain after fixation in formalin. The mammillary bodies are smaller than normal in most cases of chronic WKS. However in this study it was found that the most common causes of small mammillary bodies were Alzheimer's disease and atrophy due to transneuronal degeneration secondary to lesions in the hippocampus.

Url:

https://api.istex.fr/document/9F7BA68D52E2AABBA6C41F8875F008BEE46A1340/fulltext/pdf

DOI: 10.1007/BF01991779

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: In the Western world previous studies have shown that the majority of cases of the Wernicke-Korsakoff syndrome (WKS), which is caused by thiamine deficiency, occur in alcoholics. However, in France, a country with one of the highest per capita consumptions of alcohol, the prevalence of the WKS was found to be only 0.4% in a small retrospective autopsy study. This figure is compared with data sent to the authors by a number of neuropathologists from the U.S.A., Europe, Scandinavia and Australia. There was no obvious correlation between the prevalence rates of the WKS, which were highest in Australia (2.8% - previously published), and per capita consumption of alcohol. Other issues such as diet, National programs for supplementation of foods with thiamine, and drinking habits are considered. The pathological diagnosis of the WKS can often be made on macroscopic examination of the brain after fixation in formalin. The mammillary bodies are smaller than normal in most cases of chronic WKS. However in this study it was found that the most common causes of small mammillary bodies were Alzheimer's disease and atrophy due to transneuronal degeneration secondary to lesions in the hippocampus.</div>
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An international perspective on the prevalence of the Wernicke-Korsakoff syndrome

An international perspective on the prevalence of the Wernicke-Korsakoff syndrome

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri